Nattovena is specifically formulated to support the body’s natural fibrin balancing process.

Fibrin is a protein that plays a major role in blood physiology, making it an essential component for maintaining our health and general well-being. However, fibrin overproduction and impaired fibrin degradation has been implicated in many of today’s most common circulatory challenges.

What is Nattokinase?

Nattokinase is a fibrinolytic (fibrin-dissolving) enzyme originally discovered within a Japanese fermented soybean food called natto. The dish consists of soybeans fermented with a strain of Bacillus subtilis bacteria that in turn produce the enzyme, which upon its discovery was later named after the respective dish. The fermented dish, natto, has a slimy texture, sour taste and strong smell that is very unappealing to some. Despite its questionable taste, natto has been shown in numerous studies to have many health benefits. For its use in nutritional supplements, the nattokinase enzyme is extracted and purified in a laboratory setting.

Nattovena provides twice the potency of ordinary nattokinase products available and is naturally acid stable in the stomach since it is derived from a food source. This gives Nattovena the added benefit of not having to use an enteric coating or plastic to protect it from stomach acid. Nattovena’s formula contains the highest Fibrinolytic Unit (FU) activity among the major brands of nattokinase supplements, supplying 4,000 fibrinolytic units per capsule, thereby optimizing support for normal blood viscosity and cardiac function.

How Does Nattokinase Work?

Fibrin is naturally produced in the body by a protein called thrombin and is degraded by the body's own fibrinolytic enzyme, plasmin. Fibrin is typically produced during the recovery and healing processes caused by injury or other health concerns. Usually, these processes exist in a delicate balance; however, many conditions can impair fibrin degradation and lead to excessive levels of fibrin within the body. Nattokinase maintains the body’s normal fibrin removal process.

Clinical Studies

Clinical studies on nattokinase have demonstrated that healthy adults that used nattokinase maintained normal concentrations of fibrinogen within the blood plasma. Examination of blood taken from patients supplementing oral nattokinase revealed the presence of the enzyme intact in the blood and that this enzyme was functionally capable of supporting the body’s natural fibrin balancing process. In this clinical setting, nattokinase was shown to work systemically throughout the body (the circulatory system) as opposed to within the confines of the digestive tract, like typical digestive enzymes.

Cardiovascular health is the area where nattokinase has probably proven to be the most beneficial. The significance of this effect cannot be understated, especially since cardiovascular disease is the leading cause of death in the United States. Although there are around 20 enzymes in the body which are responsible for creating blood clots, there is only one enzyme, plasmin, which is responsible for dissolving them. As we age though, the production of plasmin slows down and the body is unable to dissolve clots as easily. In addition to a decrease in plasmin production, we also experience an increase in fibrinogen levels. When the levels of fibrinogen increase, platelet aggregation also increases along with an increased risk in blood clots forming throughout the body. Every aging adult is faced with these cardiovascular challenges as they become deficient in blood cleansing enzymes, especially plasmin. Nattokinase supplementation satisfies this age-related enzyme deficiency and healthy individuals should consider adding nattokinase to their diet to support normal amounts of these enzymes. Research on this enzyme has demonstrated that it has an unmatched ability to control these natural imbalances as we age, providing much needed support to the cardiovascular system.

Suggested Use

Directions: Take Nattovena with 8 oz of water on an empty stomach. Higher doses may be divided into 2 or 3 servings per day, but it is recommended to not exceed 9 capsules in any 24-hour period unless otherwise directed by a healthcare practitioner.*

Maintenance: 2 Capsules per day.*

Increased Support: 4 Capsules per day.*

Therapeutic: 6 Capsules per day.*

Warning: Do not take this product without the consent of your physician if you are currently taking blood thinning medications or if you are pregnant or nursing.

Frequently Asked Questions

Studies have demonstrated that nattokinase improves overall circulation, promotes healthy blood viscosity, promotes healthy clotting factors, keeps blood cells from sticking together, and maintains blood pressure levels already within normal range.*
Nattovena supports normal clot formation by maintaining normal levels of blood coagulation factors.* It also supports normal clot breakdown by maintaining normal fibrinolytic (clot-dissolving) activity, due to its ability to also increase the production of the body's inherent fibrinolytic enzyme plasmin.*
Fibrin is a vital protein that forms in response to trauma, injury, or even in cases of autoimmune conditions. The body can not only overproduce fibrin in these instances, but can also produce fibrin when there is no trauma or injury, which can lead to a bevy of unwanted symptoms. Fibrinolytic activity is the body’s natural way of breaking up excessive fibrin and unwanted clots.
Nattokinase is derived from natto, which has been a regular food staple within Asian cuisine for centuries. Although nattokinase has many benefits, studies have shown that it also does not have demonstrative side effects, and the ingredient is considered GRAS (generally recognized as safe) within the US.
Due to the vast array of unhealthy conditions that excessive fibrin can bring, Nattovena has far greater value than a simple cardiovascular support product. Many aspects of health, from muscle recovery, to immune and joint health are directly related to fibrin and blood viscosity.*
You should always check with your health care provider prior to taking any new dietary supplements in combination with a prescription. However, Nattovena does not contain any vitamin K, so it is assumed to be compatible with these medications since their mode of action is based on inhibiting vitamin K. Nattovena is not contraindicated with aspirin, natural supplements, or antihypertensive medications although medical supervision when implementing any new supplement regimen is always recommended.
The formula is Kosher, and a copy of the certification is available by request.
The formula is vegetarian and vegan in accordance with the guidelines of the American Vegetarian Association. For more information, please read our blog on where enzymes come from by clicking here.
The microorganisms used to produce this enzyme product are not genetically engineered organisms as defined by the National Organic Standards Board. Genetically engineered is defined as follows: Made with techniques that alter the molecular or cellular biology of an organism by means that are not possible under natural conditions or processes. Genetic engineering includes recombinant DNA, cell fusion, micro-and macro-encapsulation, gene deletion and doubling, introducing a foreign gene, and changing the position of genes. It shall not include breeding, conjugation, fermentation, hybridization, in-vitro fertilization, and tissue culture.
Yes, the specialty enzyme that makes up Nattovena is Generally Recognized as Safe (GRAS) by the FDA.

Nattovena is the world’s first ultra-concentrated 4,000 FU pure nattokinase dietary supplement, in easy-to-swallow micro-caps.

Nattovena contains ultra-refined, pharmaceutical grade, acid stable nattokinase. Nattovéna's potency is unparalleled in its class. The standard for nattokinase manufacturing is a potency of up to 2,000 FU’s, or fibrinolytic units, of fibrin degrading activity per capsule. Nattovena has broken the mold by providing 4,000 FU’s of activity, or double the ordinary dose, offering the strongest nattokinase activity per capsule, period.